Amorphous no more: subdiffraction view of the pericentriolar material architecture
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چکیده
منابع مشابه
Amorphous no more: subdiffraction view of the pericentriolar material architecture.
The centrosome influences the shape, orientation and activity of the microtubule cytoskeleton. The pericentriolar material (PCM), determines this functionality by providing a dynamic platform for nucleating microtubules and acts as a nexus for molecular signaling. Although great strides have been made in understanding PCM activity, its diffraction-limited size and amorphous appearance on electr...
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A centrosome consists of two barrel-shaped centrioles embedded in a matrix of proteins known as the pericentriolar material (PCM). The PCM serves as a platform for protein complexes that regulate organelle trafficking, protein degradation and spindle assembly. Perhaps most important for cell division, the PCM concentrates tubulin and serves as the primary organizing centre for microtubules in m...
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متن کاملMethod: In vitro analysis of pericentriolar material assembly.
Centrosomes are major microtubule-organizing centers in eukaryotic cells and play a critical role in embryonic development and asymmetric cell division. Centrosomes comprise a pair of centrioles surrounded by an amorphous proteinaceous meshwork called the pericentriolar material (PCM). Robust deposition of PCM around the centrioles is essential for a centrosome to achieve full microtubule nucle...
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ژورنال
عنوان ژورنال: Trends in Cell Biology
سال: 2014
ISSN: 0962-8924
DOI: 10.1016/j.tcb.2013.10.001